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Over the years, the absence of labels warning of the potential for toxicity has combined with the misconception of safety, leading to increasing misuse and abuse of ephedrine-containing products. Reports in the literature indicate abuse and misuse of all ephedrine products -- not just those marketed as dietary supplements but also those marketed as over-the-counter bronchodilators and decongestants. The increased availability and marketing of botanically derived ephedrine products since the passage of the Dietary Supplement Health and Education Act of 1994 contributed to the increasing number of adverse effects. (10)
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Ephedrine is derived from any of several species of the genus Ephedra. While some of the Ephedra species have no alkaloid content, the Asian species E. sinica typically has the highest concentration of ephedrine. The alkaloid content of E. sinica ranges from one to three percent; 40% to 90% of the alkaloids are ephedrine, with the remainder made up of pseudoephedrine, norephedrine and norpseudoephedrine. The pharmacological effects of E. sinica are thus principally due to its ephedrine content. (2-4)
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Ephedrine is an ingredient used in certain over the counter medications (mostly nasal drops) to treat congestion and asthma. It's a stimulant, originally derived from an Asiatic shrub, and acts on the central nervous system. Recent reports suggest an increase in recreational misuse, in which the drug is sold as pills and is taken orally (by mouth)..
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Over-the-counter bronchodilators and cold medicines containing ephedrine are required to list the concentration in each dose, recommended dosage, potential adverse effects, and contraindications. (9) However products marketed as dietary supplements have not until recently been subject to similar regulation. Ephedrine products advertised as weight-loss aids, energy enhancers, and alternatives to illegal psychoactives have been sold for years without labeling indicating the pharmacologically active content of the products, let alone any potential adverse effects, contraindications, or dosage recommendations. In fact, much product marketing and packaging leads many consumers to believe that because an ephedrine product contains only the botanical source of the drug, it is safe. (10) Some products are directly mislabeled, and the actual content of many ephedrine products may far exceed that corresponding with legitimate therapeutic doses. One product that was analyzed by the Texas Department of Public Health indicated only wild Chinese ginseng on its label, yet laboratory analysis revealed a single tablet to contain 45 mg ephedrine and 20 mg caffeine. (11)
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Over the years, the absence of labels warning of the potential for toxicity has combined with the misconception of safety, leading to increasing misuse and abuse of ephedrine-containing products. Reports in the literature indicate abuse and misuse of all ephedrine products -- not just those marketed as dietary supplements but also those marketed as over-the-counter bronchodilators and decongestants. The increased availability and marketing of botanically derived ephedrine products since the passage of the Dietary Supplement Health and Education Act of 1994 contributed to the increasing number of adverse effects. (10)
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Over the years, the absence of labels warning of the potential for toxicity has combined with the misconception of safety, leading to increasing misuse and abuse of ephedrine-containing products. Reports in the literature indicate abuse and misuse of all ephedrine products -- not just those marketed as dietary supplements but also those marketed as over-the-counter bronchodilators and decongestants. The increased availability and marketing of botanically derived ephedrine products since the passage of the Dietary Supplement Health and Education Act of 1994 contributed to the increasing number of adverse effects. (10)
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Ephedrine is a sympathomimetic that acts directly and indirectly on the sympathetic nerves. Its bronchodilating effects are the result of relaxation of bronchial smooth muscle through direct stimulation of ? adrenergic receptors. It is nasal decongestant, and has been used therapeutically for nocturnal enuresis, diabetic neuropathic edema, dysmenorrhea, narcolepsy, and myasthenia gravis. (5,6) Ephedrine in combination with caffeine has been shown to promote thermogenesis, fat loss, and muscle gain in several controlled trials. (7,8) Ephedrine is metabolized to norephedrine (phenylpropanolamine) which is responsible for the central nervous system stimulating effects of the drug. (5,6)
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Therapeutic doses for bronchodilation range from 12.5 to 50 mg three times per day, with maximum daily doses between 120 and 150 mg. Because of its indirect effect on neurotransmitter stores, long-term use of ephedrine can lead to tachyphylaxis. Increasing dosage can induce toxic effects, including peripheral vasconstriction and cardiac stimulation, leading to increased blood pressure and increased heart rate; adverse effects on the central nervous system include nervousness, anxiety, tremor, weakness, irritability and insomnia. These effects increase with high doses, and overdose leads to nausea, vomiting, fever, palpitations, tachycardia, hypertension, paranoid psychosis, respiratory depression, convulsions and coma. (5,6)
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Reports of undesirable side-effects are widespread, and lawsuits are pending in the states concerning a number of deaths alleged to be associated with ephedrine use. Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. Ephedrine is commonly used as a stimulant, appetite suppressant, concentraton aid, decongestant and to treat hypotension associated with regional anaesthesia. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It is most usually marketed in the hydrochloride and sulfate forms.
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Ephedrine is derived from any of several species of the genus Ephedra. While some of the Ephedra species have no alkaloid content, the Asian species E. sinica typically has the highest concentration of ephedrine. The alkaloid content of E. sinica ranges from one to three percent; 40% to 90% of the alkaloids are ephedrine, with the remainder made up of pseudoephedrine, norephedrine and norpseudoephedrine. The pharmacological effects of E. sinica are thus principally due to its ephedrine content. (2-4)
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Ephedrine is derived from any of several species of the genus Ephedra. While some of the Ephedra species have no alkaloid content, the Asian species E. sinica typically has the highest concentration of ephedrine. The alkaloid content of E. sinica ranges from one to three percent; 40% to 90% of the alkaloids are ephedrine, with the remainder made up of pseudoephedrine, norephedrine and norpseudoephedrine. The pharmacological effects of E. sinica are thus principally due to its ephedrine content. (2-4).
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Ephedrine is an ingredient used in certain over the counter medications (mostly nasal drops) to treat congestion and asthma. It's a stimulant, originally derived from an Asiatic shrub, and acts on the central nervous system. Recent reports suggest an increase in recreational misuse, in which the drug is sold as pills and is taken orally (by mouth).
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Ephedrine is a sympathomimetic that acts directly and indirectly on the sympathetic nerves. Its bronchodilating effects are the result of relaxation of bronchial smooth muscle through direct stimulation of ? adrenergic receptors. It is nasal decongestant, and has been used therapeutically for nocturnal enuresis, diabetic neuropathic edema, dysmenorrhea, narcolepsy, and myasthenia gravis. (5,6) Ephedrine in combination with caffeine has been shown to promote thermogenesis, fat loss, and muscle gain in several controlled trials. (7,8) Ephedrine is metabolized to norephedrine (phenylpropanolamine) which is responsible for the central nervous system stimulating effects of the drug. (5,6).
Therapeutic doses for bronchodilation range from 12.5 to 50 mg three times per day, with maximum daily doses between 120 and 150 mg. Because of its indirect effect on neurotransmitter stores, long-term use of ephedrine can lead to tachyphylaxis. Increasing dosage can induce toxic effects, including peripheral vasconstriction and cardiac stimulation, leading to increased blood pressure and increased heart rate; adverse effects on the central nervous system include nervousness, anxiety, tremor, weakness, irritability and insomnia. These effects increase with high doses, and overdose leads to nausea, vomiting, fever, palpitations, tachycardia, hypertension, paranoid psychosis, respiratory depression, convulsions and coma. (5,6)
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Ephedrine is an ingredient used in certain over the counter medications (mostly nasal drops) to treat congestion and asthma. It's a stimulant, originally derived from an Asiatic shrub, and acts on the central nervous system. Recent reports suggest an increase in recreational misuse, in which the drug is sold as pills and is taken orally (by mouth). ephedrine free diet pill The risks: ephedrine diet The effects:
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Over the years, the absence of labels warning of the potential for toxicity has combined with the misconception of safety, leading to increasing misuse and abuse of ephedrine-containing products. Reports in the literature indicate abuse and misuse of all ephedrine products -- not just those marketed as dietary supplements but also those marketed as over-the-counter bronchodilators and decongestants. The increased availability and marketing of botanically derived ephedrine products since the passage of the Dietary Supplement Health and Education Act of 1994 contributed to the increasing number of adverse effects. (10)
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